| Summary: |
Hypertension is an important risk
factor for coronary disease. This happens both
in developed or developing country. Starfruit
(Averrhoa bilimbi L.) has chemical constituents
that are benefi cial for health. Phytochemical
screening showed that crude drugs starfruit
leaves contain fl avonoids, saponins, tannins
and steroids/triterpenoids. Tannin has diuretic
eff ect. Tannin and fl avonoid also contain
antioxidants that can decrease blood pressure.
Objective: To determine of the eff ect of starfruit
leaf extract to decrease blood pressure of
hypertension white rats (Rattus norvegicus).
Methods: This study was a pure experimental
research design with pretest-posttest control
group. The Number of samples was 21 white
rats, which had previously been induced with
2.5% NaCl and prednisone dose of 1.5 mg/kg
BW for 15 days. The samples were divided into 3
groups; group 1 was given captopril treatment
dose of 2.5 mg/kg BW, group 2 was given a dose
of starfruit leaf extract 52.517 mg/100 gram BW;
and group 3 was given doses of leaf starfruit
extract 105.034 mg/100 gram BW of the rats.
Treatment was given for 15 days and then the
blood pressure of the white rats was measured.
Results: captopril dose 2.5 mg/kg BW was
eff ective to decrease the white rats blood
pressure (P <0.05). The Starfruit leaf extract
dose 52. 517 mg/100 gram BW was eff ective
to decrease white rats blood pressure (P <0.05)
and starfruit leaf extract dose 105. 034 mg/100
gram BW was eff ective to decrease white rats
blood pressure (p< 0.05).
Conclusion: captopril dose 2.5 mg/kg BW and
starfruit leaf extract dose 105. 034 mg/100 gram
BW mice had similar eff ectiveness to decrease
white rats blood pressure.
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