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EFEK KO-KEMOTERAPI EKSTRAK BIJI PETAI (Parkia speciosa) DENGAN DOXORUBICIN TERHADAP TOKSISITAS SEL JANTUNG PADA TIKUS (Sprague dawley) MODEL KANKER LIDAH

Doxorubicin is widely used chemotherapy agent. However, its activity induces cardiotoxicity by iron-mediated free radicals formation. Co-chemotherapy which combine conventional chemotherapy such as Doxorubicin with herbal was expected to reduce cardiotoxicity. Petai seed extract (Parkia speciosa) co...

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Main Author: Arya Nur Ihsan
Format: Skripsi S1
Language: Bahasa Indonesia
Published: FKG 16 UMY 057 2016
Subjects:
Doxorubicin, Parkia speciosa, 4
NQO, cardiotoxicity, co
chemotherapy.
Online Access: http://oaipmh-jogjalib.umy.ac.idkatalog.php?opo=lihatDetilKatalog&id=71903
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id oai:lib.umy.ac.id:71903
recordtype oai_dc
spelling oai:lib.umy.ac.id:719032021-06-16T13:09:18ZEFEK KO-KEMOTERAPI EKSTRAK BIJI PETAI (Parkia speciosa) DENGAN DOXORUBICIN TERHADAP TOKSISITAS SEL JANTUNG PADA TIKUS (Sprague dawley) MODEL KANKER LIDAHArya Nur IhsanDoxorubicin, Parkia speciosa, 4NQO, cardiotoxicity, cochemotherapy.Doxorubicin is widely used chemotherapy agent. However, its activity induces cardiotoxicity by iron-mediated free radicals formation. Co-chemotherapy which combine conventional chemotherapy such as Doxorubicin with herbal was expected to reduce cardiotoxicity. Petai seed extract (Parkia speciosa) contains flavonoid which were allegedly suitable co-chemotherapy agent for its properties as antioxidant and iron chelating agent. The purpose of this paper was to evaluate co-chemotherapy effect of petai seed (Parkia speciosa) extract with Doxorubicin against cardiotoxicity in tongue cancer rat (Sprague dawley) model. 42 rats were collected and divided into 6 groups. Group 1 is negavtive control, group 2-6 were given exposure to carcinogenic (4-NQO) as cancer models for 12 weeks. After 12 weeks, group 2-6 recieved treatment. Group 2 were given only aquades, Group 3 were given Doxorubicin 4,6mg/KgBW and Group 4, 5, 6 were given 100, 200, 400 mg/KgBW of petai seed extract (Parkia speciosa) combined with 4,6mg/KgBW of Doxorubicin. This treatment was perfomed for 14 days. In 14th week heart tissue of rats were necropted, stained using Hematoxylin-Eosin (HE) and observed. The damage was evaluated based on its precentage and damage scale.FKG 16 UMY 0572016Skripsi S136 halSKR FKIK 057Bahasa Indonesiahttp://oaipmh-jogjalib.umy.ac.idkatalog.php?opo=lihatDetilKatalog&id=71903
institution Universitas Muhammadiyah Yogyakarta
collection Perpustakaan Yogyakarta
language Bahasa Indonesia
topic Doxorubicin, Parkia speciosa, 4
NQO, cardiotoxicity, co
chemotherapy.
spellingShingle Doxorubicin, Parkia speciosa, 4
NQO, cardiotoxicity, co
chemotherapy.
Arya Nur Ihsan
EFEK KO-KEMOTERAPI EKSTRAK BIJI PETAI (Parkia speciosa) DENGAN DOXORUBICIN TERHADAP TOKSISITAS SEL JANTUNG PADA TIKUS (Sprague dawley) MODEL KANKER LIDAH
description Doxorubicin is widely used chemotherapy agent. However, its activity induces cardiotoxicity by iron-mediated free radicals formation. Co-chemotherapy which combine conventional chemotherapy such as Doxorubicin with herbal was expected to reduce cardiotoxicity. Petai seed extract (Parkia speciosa) contains flavonoid which were allegedly suitable co-chemotherapy agent for its properties as antioxidant and iron chelating agent. The purpose of this paper was to evaluate co-chemotherapy effect of petai seed (Parkia speciosa) extract with Doxorubicin against cardiotoxicity in tongue cancer rat (Sprague dawley) model. 42 rats were collected and divided into 6 groups. Group 1 is negavtive control, group 2-6 were given exposure to carcinogenic (4-NQO) as cancer models for 12 weeks. After 12 weeks, group 2-6 recieved treatment. Group 2 were given only aquades, Group 3 were given Doxorubicin 4,6mg/KgBW and Group 4, 5, 6 were given 100, 200, 400 mg/KgBW of petai seed extract (Parkia speciosa) combined with 4,6mg/KgBW of Doxorubicin. This treatment was perfomed for 14 days. In 14th week heart tissue of rats were necropted, stained using Hematoxylin-Eosin (HE) and observed. The damage was evaluated based on its precentage and damage scale.
format Skripsi S1
author Arya Nur Ihsan
author_sort Arya Nur Ihsan
title EFEK KO-KEMOTERAPI EKSTRAK BIJI PETAI (Parkia speciosa) DENGAN DOXORUBICIN TERHADAP TOKSISITAS SEL JANTUNG PADA TIKUS (Sprague dawley) MODEL KANKER LIDAH
title_short EFEK KO-KEMOTERAPI EKSTRAK BIJI PETAI (Parkia speciosa) DENGAN DOXORUBICIN TERHADAP TOKSISITAS SEL JANTUNG PADA TIKUS (Sprague dawley) MODEL KANKER LIDAH
title_full EFEK KO-KEMOTERAPI EKSTRAK BIJI PETAI (Parkia speciosa) DENGAN DOXORUBICIN TERHADAP TOKSISITAS SEL JANTUNG PADA TIKUS (Sprague dawley) MODEL KANKER LIDAH
title_fullStr EFEK KO-KEMOTERAPI EKSTRAK BIJI PETAI (Parkia speciosa) DENGAN DOXORUBICIN TERHADAP TOKSISITAS SEL JANTUNG PADA TIKUS (Sprague dawley) MODEL KANKER LIDAH
title_full_unstemmed EFEK KO-KEMOTERAPI EKSTRAK BIJI PETAI (Parkia speciosa) DENGAN DOXORUBICIN TERHADAP TOKSISITAS SEL JANTUNG PADA TIKUS (Sprague dawley) MODEL KANKER LIDAH
title_sort efek ko-kemoterapi ekstrak biji petai (parkia speciosa) dengan doxorubicin terhadap toksisitas sel jantung pada tikus (sprague dawley) model kanker lidah
physical 36 hal
publisher FKG 16 UMY 057
publishDate 2016
url http://oaipmh-jogjalib.umy.ac.idkatalog.php?opo=lihatDetilKatalog&id=71903
isbn SKR FKIK 057
_version_ 1702752648189444096
score 14.79448

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