Cyclooxygenase-2 Gene 765 single nucleotide polymorphism as a protective factor against periodontitis in Taiwanese
Aim: Prostaglandin E2 (PGE2) is considered to be an important mediator of tissue destruction in periodontitis. The cyclooxygenase (COX) catalyses the production of PGs. COX-2, which is induced in an inflammatory response, is responsible for PGs synthesis at sites of inflammation. A single nucleot...
| Main Author: | Ya-Ping Ho, Ying-Chu Lin |
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| Format: | Koleksi Audio Visual |
| Language: | Bahasa Inggris |
| Published: |
Blackwell Synergy
2008
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| Subjects: | |
| Online Access: |
http://oaipmh-jogjalib.umy.ac.idkatalog.php?opo=lihatDetilKatalog&id=93205 |
| Summary: |
Aim: Prostaglandin E2 (PGE2) is considered to be an important mediator of tissue
destruction in periodontitis. The cyclooxygenase (COX) catalyses the production of
PGs. COX-2, which is induced in an inflammatory response, is responsible for PGs
synthesis at sites of inflammation. A single nucleotide polymorphism of COX-2 765
has been shown to alter the expression of the COX-2 gene. The purpose of the present
study was to evaluate the association of the COX-2 765 polymorphism and
susceptibility to periodontitis in Taiwanese. |
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