Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in Turkish patients with generalized aggressive periodontitis
Aim: Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) have important roles in proteolytic events in periodontitis. The aim of this study was to investigate TPA and PAI-1 gene polymorphisms in relation to susceptibility to generalized aggressive periodontitis (G-Ag...
| Main Author: | Gu¨ lnur Emingil |
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| Format: | Koleksi Audio Visual |
| Language: | Bahasa Inggris |
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Blackwell Synergy
2007
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http://oaipmh-jogjalib.umy.ac.idkatalog.php?opo=lihatDetilKatalog&id=93449 |
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oai:lib.umy.ac.id:93449 |
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oai:lib.umy.ac.id:934492021-06-16T13:12:36ZGene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in Turkish patients with generalized aggressive periodontitisGu¨ lnur Emingil Aim: Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) have important roles in proteolytic events in periodontitis. The aim of this study was to investigate TPA and PAI-1 gene polymorphisms in relation to susceptibility to generalized aggressive periodontitis (G-AgP). Methods: Genomic DNA was obtained from peripheral blood of 90 G-AgP patients and 154 periodontally healthy subjects. 4G/5G polymorphism in the promoter region of the PAI-1 gene and Alu-repeat insertion/deletion (I/D) polymorphism in intron 8 of the TPA gene were genotyped by polymerase chain reaction and endonuclease digestion. Results: The genotype distributions of TPA and PAI-1 genes were similar between G-AgP and healthy subjects (p>0.05). The distribution of TPA genotypes in G-AgP patients was 33.4% D/D, 44.4% I/D, and 22.2% I/I and was 26.3% D/D, 40.4% I/D, and 33.3% I/I in healthy subjects. The D allele was 55.6% in G-AgP and 46.6% in healthy subjects. There was a significant difference among study groups in D allele frequencies (p50.044). The PAI-1 genotype distribution in G-AgP was 29.1% 4G/4G, 43.0% 4G/5G, and 27.9% 5G/5G, while it was 35.7% 4G/4G, 43.8% 4G/5G, and 20.5% 5G/5G in healthy subjects. Conclusion: These data suggest that the D polymorphic allele of TPA gene polymorphism could be associated with susceptibility to G-AgP in Turkish subjects.Blackwell Synergy2007Koleksi Audio Visual Bahasa Inggrishttp://oaipmh-jogjalib.umy.ac.idkatalog.php?opo=lihatDetilKatalog&id=93449 |
| institution |
Universitas Muhammadiyah Yogyakarta |
| collection |
Perpustakaan Yogyakarta |
| language |
Bahasa Inggris |
| topic |
|
| spellingShingle |
Gu¨ lnur Emingil Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in Turkish patients with generalized aggressive periodontitis |
| description |
Aim: Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1
(PAI-1) have important roles in proteolytic events in periodontitis. The aim of this
study was to investigate TPA and PAI-1 gene polymorphisms in relation to
susceptibility to generalized aggressive periodontitis (G-AgP).
Methods: Genomic DNA was obtained from peripheral blood of 90 G-AgP patients
and 154 periodontally healthy subjects. 4G/5G polymorphism in the promoter
region of the PAI-1 gene and Alu-repeat insertion/deletion (I/D) polymorphism in
intron 8 of the TPA gene were genotyped by polymerase chain reaction and
endonuclease digestion.
Results: The genotype distributions of TPA and PAI-1 genes were similar between
G-AgP and healthy subjects (p>0.05). The distribution of TPA genotypes in G-AgP
patients was 33.4% D/D, 44.4% I/D, and 22.2% I/I and was 26.3% D/D, 40.4% I/D,
and 33.3% I/I in healthy subjects. The D allele was 55.6% in G-AgP and 46.6% in
healthy subjects. There was a significant difference among study groups in D allele
frequencies (p50.044). The PAI-1 genotype distribution in G-AgP was 29.1% 4G/4G,
43.0% 4G/5G, and 27.9% 5G/5G, while it was 35.7% 4G/4G, 43.8% 4G/5G, and
20.5% 5G/5G in healthy subjects.
Conclusion: These data suggest that the D polymorphic allele of TPA gene
polymorphism could be associated with susceptibility to G-AgP in Turkish subjects. |
| format |
Koleksi Audio Visual |
| author |
Gu¨ lnur Emingil |
| author_sort |
Gu¨ lnur Emingil |
| title |
Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in Turkish patients with generalized aggressive periodontitis |
| title_short |
Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in Turkish patients with generalized aggressive periodontitis |
| title_full |
Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in Turkish patients with generalized aggressive periodontitis |
| title_fullStr |
Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in Turkish patients with generalized aggressive periodontitis |
| title_full_unstemmed |
Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in Turkish patients with generalized aggressive periodontitis |
| title_sort |
gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in turkish patients with generalized aggressive periodontitis |
| publisher |
Blackwell Synergy |
| publishDate |
2007 |
| url |
http://oaipmh-jogjalib.umy.ac.idkatalog.php?opo=lihatDetilKatalog&id=93449 |
| _version_ |
1702756909383155712 |
| score |
14.79448 |