The new concept of periodontal disease pathogenesis requires new and novel therapeutic strategies
In this issue Bostanci et al. (2007) demonstrate that receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) were oppositely regulated in gingival crevice fluid (GCF) from periodontitis patients. RANKL, RANK and OPG are key molecules that regulate osteoclast recruitment, differentia...
| Main Author: | Martin A. Taubman |
|---|---|
| Format: | Koleksi Audio Visual |
| Language: | Bahasa Inggris |
| Published: |
Blackwell Synergy
2007
|
| Subjects: | |
| Online Access: |
http://oaipmh-jogjalib.umy.ac.idkatalog.php?opo=lihatDetilKatalog&id=93513 |
| Summary: |
In this issue Bostanci et al. (2007) demonstrate that receptor activator of NF-kB ligand
(RANKL) and osteoprotegerin (OPG) were oppositely regulated in gingival crevice
fluid (GCF) from periodontitis patients. RANKL, RANK and OPG are key molecules
that regulate osteoclast recruitment, differentiation and activation. New concepts of the
pathogenesis of periodontitis have implicated inflammation triggered by host immune
response to periodontal biofilm microorganisms(s) in disease. Host response to
bacteria involves activation of T and B cells in the inflammatory infiltrate which bear
abundant RANKL that promotes osteoclastic bone resorption. Periodontal tissue
destruction can be ameliorated by immunobiological interference with immune cell
RANKL expression or function. The new disease concepts provide a foundation to
build biological approaches to target RANKL production in periodontal lesions. |
|---|