Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease
Objectives: This study evaluated the effects of scaling and root planing (SRP) sub-antimicrobial dose doxycycline (SDD) on gingival crevicular fluid (GCF) levels of matrix metalloproteinase (MMP) -1, -8, -13 and on serum levels of high-sensitivity C-reactive protein (HsCRP) and lipid fractions i...
| Main Author: | Gu¨ lay Tu¨ ter |
|---|---|
| Format: | Koleksi Audio Visual |
| Language: | Bahasa Inggris |
| Published: |
Blackwell Synergy
2007
|
| Subjects: | |
| Online Access: |
http://oaipmh-jogjalib.umy.ac.idkatalog.php?opo=lihatDetilKatalog&id=93587 |
| id |
oai:lib.umy.ac.id:93587 |
|---|---|
| recordtype |
oai_dc |
| spelling |
oai:lib.umy.ac.id:935872021-06-16T13:12:39ZEffects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery diseaseGu¨ lay Tu¨ ter Objectives: This study evaluated the effects of scaling and root planing (SRP) sub-antimicrobial dose doxycycline (SDD) on gingival crevicular fluid (GCF) levels of matrix metalloproteinase (MMP) -1, -8, -13 and on serum levels of high-sensitivity C-reactive protein (HsCRP) and lipid fractions in patients with both chronic periodontitis (CP) and coronary artery disease (CAD). Material and Methods: Thirty-six patients were randomly distributed into two groups (Placebo or SDD; 6 weeks) and both received two regimens of SRP. At baseline and 6 weeks, GCF and blood were collected and clinical indices were recorded. MMPs, HsCRP and lipid fractions were assayed. Results: There were statistically significant improvements for all clinical parameters, GCF volumes, GCF MMPs and serum levels of HsCRP, apolipoprotein-A (APO-A), high-density lipoprotein (HDL) and lipoprotein-a between pre- and post-treatment in both groups. Between groups, there were statistically significant greater improvements in pocket depth (PD), gingival index (GI), APO-A and HDL, favouring the group receiving SDD adjunctive to SRP (po0.05). Conclusion: Greater improvement was detected for PD and GI, and for serum levels of APO-A and HDL cholesterol when using SRP1SDD compared with SRP1placebo in this study. An investigation with larger numbers of patients and a longer duration of drug treatment is needed to confirm these preliminary findings.Blackwell Synergy2007Koleksi Audio Visual Bahasa Inggrishttp://oaipmh-jogjalib.umy.ac.idkatalog.php?opo=lihatDetilKatalog&id=93587 |
| institution |
Universitas Muhammadiyah Yogyakarta |
| collection |
Perpustakaan Yogyakarta |
| language |
Bahasa Inggris |
| topic |
|
| spellingShingle |
Gu¨ lay Tu¨ ter Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease |
| description |
Objectives: This study evaluated the effects of scaling and root planing (SRP) sub-antimicrobial dose doxycycline (SDD) on gingival crevicular fluid (GCF) levels of
matrix metalloproteinase (MMP) -1, -8, -13 and on serum levels of high-sensitivity
C-reactive protein (HsCRP) and lipid fractions in patients with both chronic
periodontitis (CP) and coronary artery disease (CAD).
Material and Methods: Thirty-six patients were randomly distributed into two
groups (Placebo or SDD; 6 weeks) and both received two regimens of SRP. At baseline
and 6 weeks, GCF and blood were collected and clinical indices were recorded.
MMPs, HsCRP and lipid fractions were assayed.
Results: There were statistically significant improvements for all clinical parameters,
GCF volumes, GCF MMPs and serum levels of HsCRP, apolipoprotein-A (APO-A),
high-density lipoprotein (HDL) and lipoprotein-a between pre- and post-treatment in
both groups. Between groups, there were statistically significant greater improvements
in pocket depth (PD), gingival index (GI), APO-A and HDL, favouring the group
receiving SDD adjunctive to SRP (po0.05).
Conclusion: Greater improvement was detected for PD and GI, and for serum levels
of APO-A and HDL cholesterol when using SRP1SDD compared with SRP1placebo
in this study. An investigation with larger numbers of patients and a longer duration of
drug treatment is needed to confirm these preliminary findings. |
| format |
Koleksi Audio Visual |
| author |
Gu¨ lay Tu¨ ter |
| author_sort |
Gu¨ lay Tu¨ ter |
| title |
Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease |
| title_short |
Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease |
| title_full |
Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease |
| title_fullStr |
Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease |
| title_full_unstemmed |
Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease |
| title_sort |
effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease |
| publisher |
Blackwell Synergy |
| publishDate |
2007 |
| url |
http://oaipmh-jogjalib.umy.ac.idkatalog.php?opo=lihatDetilKatalog&id=93587 |
| _version_ |
1702756943002599424 |
| score |
14.79448 |