| Summary: |
Aim: The aim of this study was to evaluate common human leucocyte antigen
(HLA) associations in patients with juvenile idiopathic arthritis (N5110), in patients
with generalized aggressive periodontitis (N550) and in patients with chronic
periodontitis (N5102) in comparison to healthy controls (no periodontitis, no arthritis
N5102).
Material and methods: HLA-class I and II markers were determined using
microlymphocytotoxicity test and polymerase chain reaction with sequence specific
primers. Statistical analyses were carried out by w2-test and Yates’ correction. If no5
Fisher’s exact test was performed. In the arthritis group the influence of HLA on
attachment loss was determined by using backwards logistic regression considering
age, gender, smoking, plaque level, and the duration of the disease.
Results: In comparison with the controls HLA-DRB3n occurred more frequently in
both females suffering from juvenile idiopathic arthritis (74.58% versus 54.54%,
p50.024) and females suffering from chronic periodontitis (73.02% versus 54.54%,
p50.035). Furthermore, among patients with juvenile idiopathic arthritis an increased
odds ratio (OR) for attachment loss was found in subjects who expressed HLA-An01
(OR54.6, p50.014) or HLA-An01:DRB3n (OR54.3, p50.031).
Conclusion: HLA-DRB3n could be a common putative risk indicator for juvenile
idiopathic arthritis and chronic periodontitis among females.
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