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Are there common human leucocyte antigen associations in juvenile idiopathic arthritis and periodontitis?

Aim: The aim of this study was to evaluate common human leucocyte antigen (HLA) associations in patients with juvenile idiopathic arthritis (N5110), in patients with generalized aggressive periodontitis (N550) and in patients with chronic periodontitis (N5102) in comparison to healthy controls (n...

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Main Author: Stefan Reichert
Format: Koleksi Audio Visual
Language: Bahasa Inggris
Published: Blackwell Synergy 2007
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Online Access: http://oaipmh-jogjalib.umy.ac.idkatalog.php?opo=lihatDetilKatalog&id=93535
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spelling oai:lib.umy.ac.id:935352021-06-16T13:12:38ZAre there common human leucocyte antigen associations in juvenile idiopathic arthritis and periodontitis?Stefan Reichert Aim: The aim of this study was to evaluate common human leucocyte antigen (HLA) associations in patients with juvenile idiopathic arthritis (N5110), in patients with generalized aggressive periodontitis (N550) and in patients with chronic periodontitis (N5102) in comparison to healthy controls (no periodontitis, no arthritis N5102). Material and methods: HLA-class I and II markers were determined using microlymphocytotoxicity test and polymerase chain reaction with sequence specific primers. Statistical analyses were carried out by w2-test and Yates’ correction. If no5 Fisher’s exact test was performed. In the arthritis group the influence of HLA on attachment loss was determined by using backwards logistic regression considering age, gender, smoking, plaque level, and the duration of the disease. Results: In comparison with the controls HLA-DRB3n occurred more frequently in both females suffering from juvenile idiopathic arthritis (74.58% versus 54.54%, p50.024) and females suffering from chronic periodontitis (73.02% versus 54.54%, p50.035). Furthermore, among patients with juvenile idiopathic arthritis an increased odds ratio (OR) for attachment loss was found in subjects who expressed HLA-An01 (OR54.6, p50.014) or HLA-An01:DRB3n (OR54.3, p50.031). Conclusion: HLA-DRB3n could be a common putative risk indicator for juvenile idiopathic arthritis and chronic periodontitis among females.Blackwell Synergy2007Koleksi Audio Visual Bahasa Inggrishttp://oaipmh-jogjalib.umy.ac.idkatalog.php?opo=lihatDetilKatalog&id=93535
institution Universitas Muhammadiyah Yogyakarta
collection Perpustakaan Yogyakarta
language Bahasa Inggris
topic
spellingShingle
Stefan Reichert
Are there common human leucocyte antigen associations in juvenile idiopathic arthritis and periodontitis?
description Aim: The aim of this study was to evaluate common human leucocyte antigen (HLA) associations in patients with juvenile idiopathic arthritis (N5110), in patients with generalized aggressive periodontitis (N550) and in patients with chronic periodontitis (N5102) in comparison to healthy controls (no periodontitis, no arthritis N5102). Material and methods: HLA-class I and II markers were determined using microlymphocytotoxicity test and polymerase chain reaction with sequence specific primers. Statistical analyses were carried out by w2-test and Yates’ correction. If no5 Fisher’s exact test was performed. In the arthritis group the influence of HLA on attachment loss was determined by using backwards logistic regression considering age, gender, smoking, plaque level, and the duration of the disease. Results: In comparison with the controls HLA-DRB3n occurred more frequently in both females suffering from juvenile idiopathic arthritis (74.58% versus 54.54%, p50.024) and females suffering from chronic periodontitis (73.02% versus 54.54%, p50.035). Furthermore, among patients with juvenile idiopathic arthritis an increased odds ratio (OR) for attachment loss was found in subjects who expressed HLA-An01 (OR54.6, p50.014) or HLA-An01:DRB3n (OR54.3, p50.031). Conclusion: HLA-DRB3n could be a common putative risk indicator for juvenile idiopathic arthritis and chronic periodontitis among females.
format Koleksi Audio Visual
author Stefan Reichert
author_sort Stefan Reichert
title Are there common human leucocyte antigen associations in juvenile idiopathic arthritis and periodontitis?
title_short Are there common human leucocyte antigen associations in juvenile idiopathic arthritis and periodontitis?
title_full Are there common human leucocyte antigen associations in juvenile idiopathic arthritis and periodontitis?
title_fullStr Are there common human leucocyte antigen associations in juvenile idiopathic arthritis and periodontitis?
title_full_unstemmed Are there common human leucocyte antigen associations in juvenile idiopathic arthritis and periodontitis?
title_sort are there common human leucocyte antigen associations in juvenile idiopathic arthritis and periodontitis?
publisher Blackwell Synergy
publishDate 2007
url http://oaipmh-jogjalib.umy.ac.idkatalog.php?opo=lihatDetilKatalog&id=93535
_version_ 1702756929733918720
score 14.79448

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